Differentiation of Postembryonic Skin Endothelial Cells

Differentiation of Umbilical Cord Lining Membrane-Derived Mesenchymal Stem Cells into Endothelial-Like Cells

Background: Stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. The aim of this study was to investigate the in vitro differentiation of umbilical CL-MSC into endothelial lineage cells. Methods: In this study, isolated cells were characterized for expression of MSC-specific marke...

differentiation of murine embryonic stem cells into endothelial cells

objective: in this investigation murine embryonic stem (es) cells were differentiated into endothelial cells. materials and methods: murine es cells (cce cell line) exposed to alpha-mem medium containing 10% fbs for 4 days. then obtained flk-1 (flk-1: vascular endothelial growth factor receptor 2) positive cells were cultuted in endothelial growth medium-2 (egm-2) until the last day of experime...

Wnt signaling regulates postembryonic hypothalamic progenitor differentiation.

Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation of unspecified hypothalamic progenitors in the embryo. At later stages, inclu...

Endothelial Differentiation of Embryonic Stem Cells

Endothelial Differentiation of Mesenchymal Stromal Cells

Human mesenchymal stromal cells (hMSCs) are increasingly used in regenerative medicine for restoring worn-out or damaged tissue. Newly engineered tissues need to be properly vascularized and current candidates for in vitro tissue pre-vascularization are endothelial cells and endothelial progenitor cells. However, their use in therapy is hampered by their limited expansion capacity and lack of a...